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Brivudine trade names Zostex , Mevir , Brivir , among others is an antiviral drug occupied in the treatment of herpes zoster "shingles". Like other antivirals, it acts by inhibiting duplication of the target virus. Brivudine is used for the conduct of herpes zoster in grown patients.

It is taken verbally once daily, in contrast near aciclovir , valaciclovir and last antivirals. The drug is contraindicated in patients undergoing immunosuppression because example because of an weekly transplant or cancer therapy, singularly with fluorouracil 5-FU and chemically related pro drugs such in the role of capecitabine and tegafur , when well as the antimycotic medicine flucytosine , which is still related to 5-FU. It has not been proven to be safe in children and pregnant or breastfeeding women.

The sedate is generally well tolerated. Brivudine interacts strongly and in pink cases lethally with the anticancer drug fluorouracil 5-FU , its prodrugs and related substances. Steady topically applied 5-FU can be dangerous in combination with brivudine. This is caused by the main metabolite , bromovinyluracil BVU , irreversibly inhibiting the enzyme dihydropyrimidine dehydrogenase DPD which is necessary for inactivating 5-FU.

Taking into account a standard brivudine therapy, DPD function can be compromised allowing for regarding up to 18 days. House of payne malik online dating episode.

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  • Drugs Today (Barc). May;39(5) Brivudine: a herpes virostatic with rapid antiviral activity and once-daily dosing. Rabasseda X(1)....
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It took years for Davis, founder of The STD Project , which encourages awareness and acceptance of various sexually transmitted diseases, and spokesperson for Positive Singles , a dating site for people with STDs, to come to terms with the diagnosis she got at age
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